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Moreover, glutamate released during synaptic activity raises intracellular calcium in astroglia through metabotropic mGluR5 receptors, with the subsequent stimulation of vasoactive arachidonic acid derivatives generation, which alters the tone of pericytes and vascular smooth muscle cells [99,106,112,113,114]

Around 70% of women with PCOS experience insulin resistance, which plays a significant role in disrupted ovulation

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Adequate fluid intake helps the kidneys filter waste products effectively, though people with advanced CKD or those on dialysis may have specific fluid restrictions making personalised guidance from a renal dietitian essential

But so often it can feel out of reach for many who may have been told theyre ineligible for GLP-1s